• br Oxysterols as Key Players in Metabolic Syndrome Obesity

  2019-09-18

  

  Oxysterols as Key Players in Metabolic Syndrome? Obesity and sedentary lifestyle are on the rise and pose serious threats to people\'s health and wellbeing. Obesity is often associated with other pathologies and is one of the criteria included in the definition of metabolic syndrome (MetS) (see G

• br Concluding Remarks Recent studies have provided unprecede

  2019-09-18

  

  Concluding Remarks Recent studies have provided unprecedented details of APC/C structure and enzymology, which explain how the activity of this massive E3 ligase is controlled, and how ubiquitylation is achieved to temporally regulate cell division. Although one pervasive question has been why th

• br Results br Discussion Many

  2019-09-18

  

  Results Discussion Many studies have shown that intrinsic properties of the E2 enzyme govern the nature of the Ub modification, including both the multiplicity of the Ub modification and the specific histone deacetylase type in the case of polyubiquitin chains [3], [4], [9], [14]. Whereas pre

• br Results br Discussion C is related to

  2019-09-18

  

  Results Discussion C4 is related to another VACV protein, C16, and the C-terminal domain of C16 also inhibits DNA-PK-mediated DNA sensing via the same mechanism and to a similar level as C4. Moreover, mutagenesis of C16 at the CYC residues equivalent to those in C4 abrogated the C16-Ku interac

• br Conclusions There is significant interest

  2019-09-18

  

  Conclusions There is significant interest in understanding the contribution of biological mechanisms to the non-linear/bilinear dose–response curves for DNA-reactive agents. Model monofunctional alkylating agents have datasets amenable to PoD determination for genotoxic effects in both in vitro a

• In this study we examined

  2019-09-18

  

  In this study, we examined a possible association between the 19-bp SMI-4a and the 9-bp repeat in the DHFR gene and the risk of spina bifida in 121 mothers of a spina bifida affected child, 292 control women, 109 spina bifida patients and 234 pediatric controls using a case-control design. Furtherm

• The efficacy of A in the

  2019-09-18

  

  The efficacy of A-922500 in the ob/ob mouse model is of particular interest for two reasons. One of the most striking features of the DGAT-1 deficient mouse phenotype is the resistance to diet-induced obesity (Smith et al., 2000). However, EVP4593 of DGAT-1 in leptin deficient ob/ob mice failed to

• A number of studies have been carried out to

  2019-09-18

  

  A number of studies have been carried out to understand lipid production pathways and to increase TAGs level in higher plants. Overexpression of key glucose transport proteins of the Kennedy pathway until now is by far the most successful strategy to increase TAG lipid content in Brassica napus, Ara

• br Acknowledgement This study was supported

  2019-09-18

  

  Acknowledgement This study was supported by Vetenskapsrådet, Sweden (Grant 2017-02918). Introduction Soybean is a major source of protein and oil used for food and feed, as well as for the production of industrial products like lubricants and hydraulic fluids (Choudhary and Tran, 2011; Hsien,

• This study has several limitations First despite the

  2019-09-18

  

  This study has several limitations. First, despite the relatively large number of participants for a pharmacological neuroimaging study, sample sizes for examining the modulation of THC effects by COMT ptio pathway were small. Therefore, these particular findings should be interpreted with caution

• SC 560 kinase The present study intended to characterize the

  2019-09-18

  

  The present study intended to characterize the predominant cholinesterasic form found in tissues of three tropical fish species, namely Phalloceros harpagos Lucinda, 2008 (common name guaru), Pterygoplichthys pardalis Castelnau, 1855 (common name cascudo) and Astyanax altiparanae Garutti and Britski

• br Experimental protocols br Acknowledgements This research

  2019-09-18

  

  Experimental protocols Acknowledgements This research was funded by the Croatian Ministry of Science, Education and Sports (Programmes 098-0982915-2948 and 098-0982522-2525), the Austrian Science Fund FWF (DK-MCD W1226, SFB LIPOTOX F30, P22832), and the Croatian-Austrian Intergovernmental S&T

• Estrogens Definition and history The term estrogens

  2019-09-18

  

  Estrogens: Definition and history The term “estrogens” refers to a group of female hormones, including estrone, estradiol, estriol, and estretrol (Fig. 1). Chemically, estrogens belong to the family of organic compounds known as steroids. As such, their core structure is composed of 17 carbon-carbo

• Results are expressed as mean s e m Paired

  2019-09-18

  

  Results are expressed as mean±s.e.m. Paired or unpaired Student\'s t test was used for comparisons between 2 groups and one-way ANOVA followed by Bonferroni\'s post-test for more groups. Statistical significance was assigned if p Results and discussion Variations in [Ca2+]i in cardiomyocytes loade

• protease activated receptor Finally considering the encourag

  2019-09-17

  

  Finally, considering the encouraging inhibitory and selectivity properties of compound and against isolated CK1δ, we have also acquired a very preliminary cytotoxicity profile on human ovarian carcinoma cell line (2008) and on its cisplatin-resistant clone (C13). Results showed that after 48h of e

15342 records 986/1023 page Previous Next First page 上5页 986987988989990 下5页 Last page