• Our study provides proof of principle for dimerizing two

  2020-10-10

  

  Our study provides proof of principle for dimerizing two different E3 ligases as a novel approach to inducing one ligase to degrade the other one. The outcome of ‘ligase versus ligase’ PROTAC-mediated activity might be unpredictable a priori, but could reveal a new mechanism for proximity-mediated h

• GDC-0449 DNA damage represents a persistent threat to genomi

  2020-10-10

  

  DNA damage represents a persistent threat to genomic stability. A critical link exists between DNA mutation, chromosomal rearrangement and cancer development. In myeloid malignancies, various chromosomal translocations and/or mutations increased cellular reactive oxygen species (ROS), followed by DS

• Because conventional KO mice die within h

  2020-10-10

  

  Because conventional KO mice die within 24h of birth, it is difficult to analyze higher hoechst 33258 functions using them. Therefore, in this study, we generated brain-specific conditional DGKδ-KO mice and used these mice to perform behavioral and pharmacological tests. Results Discussion OC

• The co occurrence of the AA and the AA

  2020-10-10

  

  The co-occurrence of the AA12 and the AA8 domains in CcPDH would allow for electron transfer between these domains. Such electron transfer is known to occur in CDH, and the AA8 family in CAZy is in fact largely comprised of cytochrome domains of multi-domain CDHs. One notable exception concerns the

• The IV chains of mature GBM are

  2020-10-10

  

  The α3/α4/α5(IV)-chains of mature GBM are built exclusively by podocytes (not by endothelial cells) (Abrahamson et al., 2009), placing the podocytes into the focus of GBM-diseases such as Alport syndrome. Alport syndrome (AS) is caused by mutations in the COL4A3, 4 or 5 genes coding for the α3/α4/α5

• br Materials and methods br Results br Discussion To our

  2020-10-10

  

  Materials and methods Results Discussion To our knowledge, this is the first large-scale longitudinal measurement of more than 20 cytokines in normal pregnancy. Simultaneous measurements of several cytokines with multiplex magnetic bead-based immunoassays are becoming increasingly common in

• In the growth of cereal seeds there are two

  2020-10-10

  

  In the growth of cereal seeds there are two phases, development and germination, separated by dormancy. The developmental phase contains the three following stages: 1. early development including double fertilization which results in the formation of the diploid embryo (by fusion of the egg cell wit

• br Discussion In depression an activation of the inflammatio

  2020-10-10

  

  Discussion In depression, an activation of the inflammation process and production of cytokines (including chemotactic cytokines – chemokines) and their receptors may occur due to the stimulation of the immune system. One of the earliest studied and described cytokines in depression is interleuki

• While lowering the TID exposure of electronics is fairly str

  2020-10-10

  

  While lowering the TID exposure of electronics is fairly straightforward, there are other Trigonelline receptor induced effects that are not as easily mitigated, especially with COTS components. Single Event Effects (SEE) occur when a high-energy particle strikes the active area of an integrated ci

• Saracatinib However not all inhibitory profiles by

  2020-10-10

  

  However, not all inhibitory profiles by metals can be a priori considered artifacts of the methodology used to quantify the activity of such enzymes. Metals can indeed interfere with cholinesterases, and the mechanisms are varied. The inhibitory effect of specific metals may derive from their abilit

• Alzheimer s disease AD is

  2020-10-10

  

  Alzheimer’s disease (AD) is a chronic, progressive neurodegenerative disorder of the Teicoplanin which is considered a leading cause of dementia and affects 20–30 million people worldwide. Presently, a suitable treatment and prevention strategy against AD is hardly available. Various studies have b

• As the primary model we selected

  2020-10-10

  

  As the primary model we selected LDL-receptor knockout mice because these resemble the human plasma lipoprotein profile more closely. Currently, genetic models with reduced milk cholesterol content, which mimic cholesterol-free formula feeding, are unavailable. Thus, instead of modifying milk choles

• When a hour delay period was implemented

  2020-10-09

  

  When a 6-hour delay mi2 was implemented for the WRAM, neither of the E2-treated groups (E2-only and E2 + Levo) differed in WMC errors between the postdelay trials and the baseline trials. This suggests that exogenous E2 treatment protected from a delay-induced impairment in performance on working m

• Rice approximately covers of land area

  2020-10-09

  

  Rice approximately covers 1% of land area of the earth and it is one of the main sources of food for billions of people [4]. One of the main agriculture industry residues is rice husk, which contains high amount of amorphous silica up to 85–95%. Rice husk ash (RHA) is a solid residue of rice husk co

• EPAC induces SOCS gene expression in

  2020-10-09

  

  EPAC1 induces SOCS3 gene expression in VECs, resulting in suppression of the JAK–STAT activation initiated by the sIL-6Rα/IL-6 trans-signalling complex [67]. EPAC1 regulates SOCS3 gene induction through the activation of C/EBP and c-Jun transcription factors, which interact directly with the SOCS3 p

15417 records 804/1028 page Previous Next First page 上5页 801802803804805 下5页 Last page