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br Material and methods br
2020-09-24
Material and methods Discussion First, we investigated cannabis use, and results showed that the lifetime prevalence of cannabis use in our sample was 29.63%, with a significant difference between males (73.8% of the abusers) and females (26.2%). Moreover, the mean age and age at onset were si
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As the COMT enzyme is primarily related to
2020-09-24
As the COMT enzyme is primarily related to prefrontal dopamine degradation (e.g., Yavich et al., 2007), the present study supports the notion that prefrontal dopamine modulates retention of fear extinction rather than within-session extinction (Abraham et al., 2014). Consistent with other studies we
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A neurotoxic syndrome called Intermediate syndrome has been
2020-09-24
A neurotoxic syndrome called “Intermediate syndrome” has been described after acute cholinergic crisis, which has been interpreted as the result of pre- and postsynaptic disruptions of neuromuscular transmission (Senanayake and Karalliedde, 1987). Other toxic effects with unknown molecular targets h
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Even minor alterations in the surfactants structure
2020-09-23
Even minor alterations in the surfactants structure could have consequences on their physico-chemical characteristics; mono-RLs have less solubility, stronger surfaces sorb, and stronger cationic metals binding than homologue di-RLs (Zhang et al., 1997). The HPLC separation of RLs structure is base
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br Neurodegenerative diseases definition and categories Dise
2020-09-23
Neurodegenerative diseases: definition and categories Diseases that their progression is dependent on the formation of protein aggregates, are generally identified as protein aggregation diseases. Most common among them is neurodegenerative diseases, in which the protein abnormally Epothilone B s
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Studies using SERPINB deficient mice established the signifi
2020-09-23
Studies using SERPINB1-deficient mice established the significant role for SERPINB1 in protecting lung antimicrobial proteins from proteolysis during microbe infection and its regulatory role in sustaining the balance of neutrophil reserve [15]. Neutrophil serine proteases (NSPs) (elastase, cathepsi
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To study the effect of DDR inhibition by imatinib nilotinib
2020-09-23
To study the effect of DDR inhibition by imatinib, nilotinib and dasatinib in a cellular environment we generated DDR1 and DDR2 expressing HEK293 cell lines by stable transfection. Of the five DDR1 splice variants we focused on the 1b variant whose over-expression has been associated with pulmonary
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A study profiling chemokine expression
2020-09-23
A study profiling chemokine expression in LCLs revealed high expression levels of CCR6, CCR7, and CCR10 and low expression of CXCR4 and CXCR5 in EBV immortalized cells. Accordingly, LCLs showed a markedly increase in migration in response to the ligands of CCR6 (CCL20), CC7 (CCL21), and CCR10 (CCL28
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tbtu Moreover in this study weak expression of
2020-09-23
Moreover, in this study, weak expression of MT1 and MT2 was also detected in the oviduct muscular layers. Although there are no reports regarding the role of MT1 and MT2 in oviduct muscular layers, previous studies have demonstrated that melatonin plays an important role in the uterine contractility
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br Concluding remark br Acknowledgements br Detection and
2020-09-23
Concluding remark Acknowledgements Detection and repair of the numerous, and potentially lethal, DNA lesions arising in human Lapatinib daily is largely mediated by an efficient system collectively termed the DNA-damage response (DDR). Paradoxically, DNA-repair processes within cancer cells
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br Materials and methods br Statistical analysis All statist
2020-09-22
Materials and methods Statistical analysis All statistical analyses were performed using SPSS software version 20. Protein hydrochloride data of DNMTs and clinicopathological parameters were collected. Mann-Whitney U Test was used to assess the differential expression of nonparametric data of
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The homologous DDRs are composed of an N terminal
2020-09-22
The homologous DDRs are composed of an N-terminal discoidin homology domain, followed by a sequence of ∼220 amino acids unique to the DDRs, a transmembrane domain, a large juxtamembrane domain, and a conserved cytoplasmic tyrosine kinase domain. In a previous study, we demonstrated that DDR activati
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br How does DDR receptor activated to
2020-09-22
How does DDR2 receptor activated to induce Osteoarthritis Alternation of joints by mechanical stress produces microcracks and deterioration of natural pores in subchondral bone provides p53 apoptosis for cross talk through diffusion of small molecules [26,27]. At early stage of OA, chondrocytes i
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br CXCR CXCR is a
2020-09-22
CXCR5 CXCR5 is a homeostatic chemokine receptor for lymphocytes and plays a critical role in the development of lymphoid organs as well as regulating the interaction between antigen presenting cells and lymphocytes (Cannons et al., 2012). It is one of the major chemokine receptors dictating norma
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Fig shows graphically the abundance distributions of the ARD
2020-09-22
Fig. 3 shows, graphically, the abundance distributions of the ARD% of the investigated data with both the CPA-NRTL and CPA-UNIQUAC models, where ARD% is defined as,in which x and x are the experimental and calculated SO2 molar compositions in the liquid phase, respectively, and N is the total number
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