• So far several methods have been used to

  2022-01-18

  

  So far, several methods have been used to monitor the level of GJC and its regulation in astrocytes studied in acute EGTA slices (see Giaume et al., 2012). This mainly includes approaches based either on electrophysiological properties of gap junction channels or on “dye coupling” experiments that

• With the nitrogen containing heterocycle

  2022-01-18

  

  With the nitrogen-containing heterocycle components and the acidic components in hand, the final products were synthesized according to the procedure as depicted in . Reaction of – with various β-substituted phenylpropionic mlkl (, and ), followed by deprotection by TFA, smoothly provided the corr

• GR activity prevents GSSG overaccumulation by

  2022-01-17

  

  GR activity prevents GSSG overaccumulation by reducing this molecule to GSH (Kranner et al., 2006). High GR activity seems to be essential for undisturbed seed germination as GR and other enzymatic antioxidants maintain sunflower (Helianthus annuus L.) seeds vigour (Bailly et al., 2002). Germination

• br Results and discussion br

  2022-01-17

  

  Results and discussion Conclusion In summary, starting from our previous lead 5046 1, we replaced the 5-nitropyrimidine core with pyrimidopyrimidine to obtain a series of novel compounds as drug candidates of GPR119 agonist for treatment of type 2 diabetes. Some derivatives showed good agonis

• br Conclusion br Author statement br Acknowledgments br

  2022-01-17

  

  Conclusion Author statement Acknowledgments Introduction The hypothalamic-pituitary-gonadal (HPG) axis is an important neurohormone network for vertebrates that regulates their gonadal development and maturation, guarantees their pubertal development and maintains their normal reproducti

• Because AM had limited efficacy on

  2022-01-17

  

  Because (AM-3189) had limited efficacy on rodent GPR40, we used two rodent models expressing human GPR40 to demonstrate efficacy of (AM-3189). First, we used human islet transplanted nude mice. In this model, endogenous pancreatic β-cells were ablated using streptozotocin, and mice were rescued to

• SCH 58261 br Ca influx through glutamate

  2022-01-17

  

  Ca2+ influx through glutamate receptors is thought to play a critical role in synaptogenesis and in the formation of neuronal circuitry during early development[45]. Because AMPA receptors might contribute to these processes, particularly at times and in cells in which NMDA receptor expression is

• Fig demonstrates placental amino acid transporter protein co

  2022-01-17

  

  Fig. 7 demonstrates placental amino selective serotonin reuptake inhibitors transporter protein concentrations. While no change in the placental SNAT2 is effected in response to a high-fat diet in wt, a trend toward a reduction was seen in glut3 mice in response to a high-fat vs. chow diet (Fig. 7A

• Contradictory results have been described regarding the role

  2022-01-17

  

  Contradictory results have been described regarding the role of the Shh pathway during vertebrate skeletal myogenesis. Different studies have shown that Shh can increase or inhibit myoblasts proliferation and terminal muscle differentiation, depending on the experimental model [[1], [2], [3], [4], [

• Piezo channels can be activated

  2022-01-17

  

  Piezo channels can be activated by many mechanical stimuli . While some of these stimulations directly mimic physiological forces experienced by no sodium salt synthesis , such as shear stress applied in a microfluidic chamber, the most commonly used modes of stimulation consist of stretching the

• The molecular nature of these putative Ca channels is

  2022-01-17

  

  The molecular nature of these putative Ca2+ Reparixin is at present unknown. Apart from the NSVDC channel, which is permeable to Ca2+ [27], [15] functional Ca2+ channels have been identified in patch clamp experiments [28]. These channels, which were characterized as B-channels, seem to have very l

• br Activators Many compounds are known to

  2022-01-17

  

  Activators Many compounds are known to influence the activity of Ca2+-activated K+ channels, and since hIK1 was cloned more insight has been gained on compounds that have the capacity to increase channel activity. Activation by divalent metal cations has been investigated, with Ca2+, Pb2+, Cd2+,

• In order to address the Cyp

  2022-01-17

  

  In order to address the Cyp inhibition issue, we tested the possibility of further changes in the heterocycle combined with reducing the electron density in the ring system by swapping the central aniline nitrogen atom for a ketone. details the synthesis of these analogs, which started with 7-bromo

• In this study we have investigated the

  2022-01-17

  

  In this study, we have investigated the expression of FXR and TGR5 in CCA tissues in two independent cohorts of patients and determined their association with tumor clinicopathological parameters. The expression of both BA receptors was also evaluated in CCA human cells and normal human cholangiocyt

• Studies of human and mouse GPR as ascertained

  2022-01-17

  

  Studies of human and mouse GPR84, as ascertained by mRNA levels in various tissues, have determined that GPR84 is highly expressed on bone marrow cells, splenic T and B cells, and circulating granulocytes/monocytes/macrophages. In the latter cells, mRNA expression of is up-regulated only under infl

15364 records 527/1025 page Previous Next First page 上5页 526527528529530 下5页 Last page