• The thermal behavior of the UV sensitive nanocomposites

  2019-08-02

  

  The thermal behavior of the UV-sensitive nanocomposites was investigated by DSC before and after irradiation in an extended temperature range (from −40 to 250 °C). Fig. 4a shows the thermograms of the non-irradiated GNP-DNA/PDMS nanocomposites in comparison with a neat PDMS sample. The filler-loaded

• br Future directions The proposed membrane topology model of

  2019-08-02

  

  Future directions The proposed membrane topology model of DGAT1 has only three TMDs, with the N-terminus oriented toward the cytosol and the C-terminus in the ER lumen. The catalytic activity is exclusively on the luminal side of the ER membrane. The second and third TM domains are only about 10

• br Cytokines and NK cells br Combined effects of cytokines

  2019-08-02

  

  Cytokines and NK cells Combined effects of cytokines and other stimuli on NK cell function Cytokine-stimulated NK AZD2014 have enhanced capacity to kill tumor cells. However, usually, individual cytokines do not seem to be sufficient for full activation, proliferation, survival and effector fu

• br Deregulation of CDK Many neurotoxic or stress

  2019-08-02

  

  Deregulation of CDK5 Many neurotoxic or stress conditions like ischemic Gap19 damage, oxidative stress, mitochondrial dysfunctions, excitotoxicity, Aβ exposure lead to disruption of the tight regulation of Cdk5 (De Strooper et al., 2010). Calpain-mediated cleavage of p35 to p25 is activated unde

• Abdominal aortic aneurysm AAA is

  2019-08-01

  

  Abdominal aortic aneurysm (AAA) is considered a major health concern and is associated with extremely high rates of mortality in case of aortic rupture. The main pathophysiologic mechanisms leading to aortic dilation include the degradation of the extracellular matrix (ECM) components, such as colla

• br Material and methods br Results br

  2019-08-01

  

  Material and methods Results Discussion The results show for the first time that DDRs may be involved in the pathogenic mechanisms of neurodegenerative diseases. We found that DDR1 and DDR2 levels are up-regulated in post-mortem AD and PD brains, suggesting that these receptors play a role

• Several functions of FAT have been suggested

  2019-08-01

  

  Several functions of FAT10 have been suggested. It has been shown that FAT10 binds noncovalently to the mitotic spindle checkpoint protein MAD2 and that this binding might cause chromosome instability in the cancer retinoid x receptor overexpressing FAT10 (Liu et al., 1999, Ren et al., 2006). In ot

• Several studies have indicated that ICT induces activation o

  2019-08-01

  

  Several studies have indicated that ICT induces activation of ERK and p38 kinase in a variety of cells. The ERK pathway was involved in and partly contributed to the neuroprotective effects in rat neuronal Retapamulin to [14] and anticancer effects in several cancer cells [5], [7], [8]. ICT could a

• Another important mediator in fear learning is

  2019-08-01

  

  Another important mediator in fear learning is the neuropeptide corticotropin-releasing factor (CRF). For example, local repeated administration of CRF into the basolateral amygdala potentiates the acquisition of cue-conditioned fear (Bijlsma et al., 2011) and CRF1 receptor antagonists effectively b

• br Proposed methodology At the outset the wind power outputs

  2019-08-01

  

  Proposed methodology At the outset, the wind power outputs must be obtained which are to be included in the OPF model. This work utilizes a modified version of the simulation method. Rather than using the simulated wind power values for each hour of the year, the probability of each wind power in

• Future advances in the in vivo molecular imaging of enzyme

  2019-08-01

  

  Future advances in the in vivo molecular imaging of enzyme activity will greatly benefit from the progress towards the quantitative detection of enzymes. Quantitative imaging requires knowledge of both the location and concentration of a specific enzyme, which is dependent on the simultaneous measu

• CYP A and CYP D are among the main

  2019-08-01

  

  CYP3A4/5 and CYP2D6 are among the main drug-metabolizing enzymes in humans that are responsible for the metabolism of more than 50% of marketed drugs [19], [21]. Drugs metabolized by CYPs are prone to drug–drug interactions, thereby modifying their response [18], [32]. Metabolic inhibition is also i

• br EBV Infection Epstein Barr

  2019-08-01

  

  EBV Infection Epstein–Barr virus (EBV, human herpesvirus 4) was discovered 50 years ago, when Epstein, Achong, and Barr used electron microscopy to identify viral particles in Burkitt\'s lymphoma cells. It belongs to the lymphocryptovirus (LCV) genus of the gammaherpesvirus subfamily (Fig. 1A). T

• All these results indicate that cleaving embryos

  2019-07-31

  

  All these results indicate that cleaving embryos possess a regulative mechanism, sensing the number of inner Cucurbitacin B and controlling the proportion of conservative and differentiative divisions of blastomeres. The current observations agree with the results from other laboratories and our pr

• Mitochondrial depolarization induced by DHODH inhibition Fig

  2019-07-31

  

  Mitochondrial depolarization induced by DHODH inhibition (Figure 5A) may also contribute to the selective effects of DHODH inhibitors on KRAS mutant cells. If so, the effect may arise more from pro-apoptotic effects of mitochondrial depolarization (Lemasters et al., 1998) than from impaired oxidativ

15319 records 1011/1022 page Previous Next First page 上5页 10111012101310141015 下5页 Last page